First, while there is no direct poison resistance, you can mitigate poison damage by maximizing chaos resistance and increasing your maximum life pool. High life reduces the impact of PoE Currency poison damage over time.
Passive nodes increasing chaos damage reduction and chaos resistance are crucial. Notables like “Born of Chaos” and cluster jewel nodes help increase survivability against poison.
Flasks that instantly recover life and grant bleed immunity indirectly help, as bleed and poison often co-occur. Use flasks with “remove bleeding” and quick charge recovery mods.
Pantheon powers such as Shakari provide significant chaos damage reduction, lowering poison damage taken during mapping and boss fights.
Avoid map mods that amplify poison damage or increase monster poison stacks unless your build is tailored to counteract them.
Playing carefully by avoiding standing in lingering poison clouds or damage over time ground effects lowers the risk of Poe 1 Divine Orb fatal damage. Mobility skills help reposition rapidly when under threat.
Finally, combining increased life recovery from passive nodes and gear with chaos resistance layers makes poison maps manageable even at high tiers.

